Details for gene set BIOCARTA_THE CO-STIMULATORY SIGNAL DURING T-CELL ACTIVATION[GSEA]

Table: GSEA Results Summary

Dataset	Set_03_wtNotch_versus_normalThy.phenotype_wtNotch_versus_normalThy.cls #wtNotch_versus_normalThy.phenotype_wtNotch_versus_normalThy.cls #wtNotch_versus_normalThy_repos
Phenotype	phenotype_wtNotch_versus_normalThy.cls#wtNotch_versus_normalThy_repos
Upregulated in class	normalThy
GeneSet	BIOCARTA_THE CO-STIMULATORY SIGNAL DURING T-CELL ACTIVATION
Enrichment Score (ES)	-0.8344449
Normalized Enrichment Score (NES)	-1.5758778
Nominal p-value	0.005586592
FDR q-value	0.12247883
FWER p-Value	0.889

Table: GSEA details [plain text format]
	PROBE	DESCRIPTION (from dataset)	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	GRB2	6650398	957	2.091	-0.0048	No
2	TRB@	3940292	2478	0.834	-0.0680	No
3	CD80	870112	2822	0.650	-0.0719	No
4	PIK3R1	4730671	7165	0.043	-0.3044	No
5	PTPN11	2230100 2470180 6100528	9168	0.008	-0.4119	No
6	PIK3CA	6220129	9883	-0.003	-0.4502	No
7	ICOSLG	70128	14566	-0.175	-0.6980	No
8	CD86	3390471 6200280	15804	-0.543	-0.7524	No
9	ICOS	1190048	16248	-0.803	-0.7583	No
10	LCK	3360142	17665	-2.357	-0.7819	Yes
11	CD28	1400739 4210093	17840	-2.716	-0.7307	Yes
12	CD3D	2810739	17940	-2.964	-0.6699	Yes
13	CD3E	3800056	18384	-4.904	-0.5844	Yes
14	CTLA4	6590537	18511	-6.266	-0.4515	Yes
15	CD3G	2680288	18515	-6.372	-0.3096	Yes
16	CD247	3800725 5720136	18546	-6.975	-0.1557	Yes
17	ITK	2230592	18551	-7.151	0.0035	Yes

Fig 3: BIOCARTA_THE CO-STIMULATORY SIGNAL DURING T-CELL ACTIVATION: Random ES distribution
Gene set null distribution of ES for BIOCARTA_THE CO-STIMULATORY SIGNAL DURING T-CELL ACTIVATION